Organisch-Chemisches Praktikum für Chemie-Ingenieurwesen TUMonline
Das Organisch-Chemische Praktikum für den Studiengang Chemieingenieurwesen vermittelt experimentelle Grundkenntnisse der präparativen Organischen Chemie. Das Praktikum wird als Stationenpraktikum unter intensiver Betreuung durch die Praktikumsassistenten durchgeführt und findet jährlich im zweiten Abschnitt der Vorlesungszeit des Wintersemesters statt. Zusätzlich dazu werden durch die Studierenden noch Seminarvorträge vorbereitet, die durch die Assistent*innen bewertet werden.
Im Wintersemester 2024/25 werden die acht Versuche blockweise voraussichtlich zwischen dem 16.01.2025 und dem 07.02.2025 durchgeführt.
Ansprechpartner: Matthias Brandl (Lehrstuhl für Biomolekulare NMR-Spektroskopie)
Kontakt: matthias.brandl (a) tum.de
Lecture
Vorlesung, 1 SWS
Zeit: Di 11:15 - 12:00
Ort: CH27401
Beginn: Dienstag 25.Oktober 2010
Kolloquiumstermine: to be announced
Terminvereinbarung: Waltraud Wolfson, Room CH32105, Tel 289-13867
E-mail:
Lecture handouts
- nmr_biopolymers_01 (structure of biopolymers, introduction)
- nmr_biopolymers_02 (NMR basic experiments: COSY, TOCSY)
- nmr_biopolymers_03 (relaxation, NOESY)
- nmr_biopolymers_04 (structure determination)
- nmr_biopolymers_05 (intrinsically disordered proteins, ligand binding, dynamics)
Lecture Biomolecular NMR-Spectroscopy (2 SWS) CH3184a
Chemie (M.Sc.): Schwerpunkt "Biolog. Chemie" (Wahlpflicht, inkl. Praktikum!), alle HF/NF (Wahlveranstaltung);
Biochemie (M.Sc.): chem. NF
4 ECTS (only lecture) / 5 ECTS (incl. Practical during summer term!)
Lecturer: Michael Sattler
Time: Friday 10:15 h - 12:00 h; starting Fri Oct 18, 2024
Location: Lecture room CH 22209. The lecture will be given live. Handouts and further information will be provided in MOODLE.
Prüfung: Modulprüfung (oral exam after lecture or after practica, resp.)
Module: for the full module (5 ECTS) participation in the Practical Biomol. NMR (CH3184b, summer term) is also required!
Content:
Basic experiments and applications of biomolecular NMR-spectroscopy
- Structure and conformation of proteins and nucleic acids
- Basic NMR experiments and information provided
- Structure determination and NMR of biological macromolecules (proteins, RNA) - AI/ML structure predictions
- Ligand binding, drug discovery
- Studying conformational dynamics by NMR
- Current topics (dynamics, IDPs, large proteins, drug discovery, in cell NMR, PREs, AI/ML)
Teaching
[Overview of NMR-Related Courses at TUM Chem. Dept.]
SS 2025Vorlesung "Biochemie 3: Biolog. Makromoküle: Struktur und Funktion" (Sattler)Vorlesung "Zellbiologie 2" (Sattler) Praktikum "Biomolecular NMR-Spectroscopy" (Gemmecker) Spektrometer-Einführung 250 MHz "Synthy" (Gemmecker, Brandl) |
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Chemisches Nebenfach "Biologische NMR-Spektroskopie" für Biochemie (M.Sc.) - Studienbeginn ab WS 2019/20
a.) Modul "Biomolecular NMR Spectroscopy" (5 ECTS) aus Vorlesung (im WS) und Praktikum (im SS, freie Zeiteinteilung), plus |
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Related NMR lectures and practicals"Quantenmechanische Grundlagen der NMR-Spektroskopie" Steffen Glaser
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Lecture Advanced NMR Spectroscopy TUMonline
Vorlesung, 3 SWS / 5 ECTS; Chemie (M.Sc.): Schwerpunkt OC (Wahlpflicht), alle HF/NF (Wahlveranstaltung)
Lecturer: G. Gemmecker Language: English
Time: Thursday, 12.15 h, seminar room CH26410; start Oct. 17th, 2024;
no lectures on Nov. 14th, 2024 and Jan 9th, 2025!
Scripts, tutorials and also last years lectures will be available in Moodle for self-learning
Examination: written exam, Fr. Feb. 21st 2025, 10:15-11.45 h, CH 26411 - please register in TUMonline ASAP!
Content: 2D NMR spectroscopy
- Basic principles of NMR spectroscopy
- Product operator formalism, principles of 2D NMR
- 2D pulse sequences for studying structure and conformation of molecules
- Nuclear Overhauser effect
- Homo- / heteronuclear NMR
Requirements:
- basic NMR knowledge (1D spectra, chemical shifts, J couplings), e.g. from "Grundlagen der analytischen Chemie"
Scripts, homework & other material:
- script, exercises etc. are available via Moodle or from below
- videos from last years lectures are also available (cf. Panopto window in Moddle, file names are refering to the chapters in the script)
Additional material (will be added during the course):
| Scripts | Tutorials / "Homework" |
Solutions | NMR spectra to play with |
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COSYDF (tar archive) CsA-1H,13C-HSQC (tar file) CsA-1H,13C-HMBC (tar file) 1H,13C-HSQC (tar archive, 3 MB) - process yourself! 1H,13C-HMBC (tar archive, 22 MB) - process yourself! |
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NEW: Spindrops visualization program for NMR |
Workspace files for import into SpinDrops: |
(thankfully provided by A. Greiner)
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